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Text Details
 
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The two bioactive GC receptors (NPR-A and NPR-B) contain three domains: (1) an extracellular domain that recognizes the ring structure of the mature natriuretic peptide; (2) a transmembrane region that undergoes conformational change during natriuretic peptide binding; and (3) the intracellular region that contains the GC-element responsible for the generation of 3',5'-guanosine cyclic monophosphate, otherwise known as cGMP, the second messenger transducing agent of the natriuretic peptide.
— Endocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart
 (book)
by Jonathan C. Schisler, Charles H Lang, Monte Willis
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| Language: | English |
| Submitted by: | Deroche1 |